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This association has been labeled 'forced normalization' or 'paradoxical normalization' (Wolf and Trimble, 1985; Pakalnis., 1987; Trimble 1991). For ECT, the comparisons with antipsychotic drugs found both treatments to be similarly effective (Fink, 1979; Fink and Sackeim, 1996; Abrams, 1997). One of the plates takes an image of the breast, and the other holds the breast in place. For the use of ECT early in the course of treatment of acutely psychotic patients, especially in first-break psychotic patients with excitement, overactivity, delusions, or florid delirium, and in those who are young, to avoid the debilitating effects of chronic illness. As our education is increasingly dominated by a pharmaceutical industry that ignores competing therapies, it becomes likely that few of the next generation of mental health workers will have experience with ECT. Breathing : take slow, deep breaths during the procedure. Br J Psychiatry 1993; 163:822-4 Denney D, Stevens. When the medications were reduced, allowing the return of seizures and EEG abnormalities, the clinical behavior improved. Combined clozapine and electroconvulsive therapy for the treatment of drug-induced psychosis in Parkinson's Disease. The successful augmentation of thiothixene by ECT in nine of nine resistant psychotic patients was reported by Friedel (1986). To assure that only treatment refractory patients were subjected to the possible toxicity of clozapine, the committees supporting such research argued that patients would have to fail two medication trials with antipsychotic drugs of two different classes, at adequate clinical dosages, each for a minimum. Internat Clin Psychopharmacology 1999; 14:69-72.
The risks of the new drugs were not yet known, so the immediate ill effects of ECT in inducing fractures and cognitive deficits tipped the clinical balance in favor of the drugs. As ECT compromises the BBB, greater amounts of clozapine penetrate to the brain without the limitations incurred by the effects on other body systems. Bolwig T, Hertz MM, Paulson OB.
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